MYC (MYC Proto-Oncogene, BHLH Transcription Factor): The MYC gene is a well-known oncogene playing a crucial role in cell cycle progression, apoptosis, and cellular transformation. It's a transcription factor that regulates the expression of numerous genes, influencing various cellular processes. Overexpression of MYC is commonly observed in a wide range of cancers, making it a significant focus in oncology research. The regulation of MYC and its pathways is a key area of study for developing targeted cancer therapies, as its dysregulation is linked to tumorigenesis, cancer progression, and resistance to therapy....



MYEOV (Myeloma Overexpressed Gene): MYEOV is often overexpressed in multiple myeloma and other cancers. It's believed to play a role in cancer cell proliferation and survival, making it a potential target for cancer therapy....



MYEOV

CA2 (Carbonic Anhydrase II): CA2 encodes an enzyme that is extremely important in the regulation of pH and fluid balance in various tissues, including the kidney. It catalyzes the reversible hydration of carbon dioxide, playing a vital role in respiratory gas exchange and acid-base balance. Mutations in CA2 can lead to conditions like osteopetrosis and renal tubular acidosis, highlighting its essential role in bone and kidney function....

MYH15 (Myosin Heavy Chain 15): MYH15 encodes a myosin heavy chain protein, predominantly found in skeletal muscle. Myosins are motor proteins involved in muscle contraction and cellular motility. The specific role and significance of MYH15 in muscle function and development are subjects of ongoing research....



MYH15

MYH6 (Myosin Heavy Chain 6): MYH6 is a gene that encodes the alpha heavy chain subunit of cardiac myosin, a motor protein found in the heart muscle. This protein plays a fundamental role in the contraction of the cardiac muscle, enabling the heart to pump blood efficiently throughout the body. The alpha heavy chain is particularly important for the atrial contraction, contributing to the initial filling phase of the ventricles. Mutations in MYH6 have been linked to various cardiac disorders, including atrial septal defects, cardiomyopathies, and heart rhythm abnormalities, underscoring its critical role in cardiac function and development. The proper...



MYH6

PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha): PIK3C2A is part of the PI3K family, playing a role in cell signaling pathways that control cell growth and survival. It's involved in the regulation of membrane trafficking, insulin signaling, and cytoskeletal dynamics. Dysregulation of PIK3C2A can contribute to various diseases, including cancer and metabolic disorders....



PIK3C2A

MYLK (Myosin Light Chain Kinase): MYLK encodes an enzyme critical for smooth muscle contraction. It phosphorylates myosin light chains, facilitating the interaction between actin and myosin, and is vital in regulating vascular tone and blood pressure. MYLK is also involved in other smooth muscle functions such as gastrointestinal motility and respiratory airway resistance. Alterations in MYLK function or expression are implicated in various disorders including asthma, hypertension, and certain types of cancer....



MYLK

MYO18A (Myosin XVIIIA): MYO18A is a unique myosin that plays a role in the organization of the cytoskeleton and in cell migration. It is involved in muscle development and function, and its abnormalities are linked to muscle disorders and possibly some forms of cancer....



MYO18A

PKD2L2 (Polycystic Kidney Disease 2-Like 2): PKD2L2 is a member of the polycystin protein family, associated with calcium channel and signaling functions. While it shares homology with proteins implicated in polycystic kidney disease, its specific role in renal physiology or disease is less clear. PKD2L2 may have broader implications in cellular signaling and calcium homeostasis....



PKD2L2

PON2 (Paraoxonase 2): PON2 encodes an enzyme that belongs to the paraoxonase family, which plays a role in detoxification and antioxidant defense. PON2 is involved in the protection against oxidative stress and lipid peroxidation, making it relevant in cardiovascular health and other oxidative stress-related conditions....



POM2

PPA2 (Inorganic Pyrophosphatase 2): PPA2 encodes an enzyme called inorganic pyrophosphatase, which catalyzes the hydrolysis of pyrophosphate (PPi) to inorganic phosphate (Pi). This enzymatic activity is important for cellular energy metabolism and nucleotide biosynthesis. Dysfunctions in PPA2 may impact energy production and nucleotide metabolism....




PPA2

Allergies

Aspergillus fumigatus is a type of mold that thrives in soil and decaying organic matter but can also be found indoors. It’s a significant allergen that can lead to respiratory conditions like allergic bronchopulmonary aspergillosis (ABPA) in susceptible individuals, particularly those with asthma or cystic fibrosis...

Aspergillus Fumigatus

Barley is a common grain used in many foods and beverages, ranging from bread and cereals to beer. For some individuals, barley can trigger an allergic reaction due to its protein content. Recognizing the symptoms and managing a barley allergy is crucial for those affected....



Barley

Bee venom allergy is a potentially life-threatening condition that occurs when an individual has an allergic reaction to bee stings. This type of allergy triggers the immune system to overreact to the proteins found in bee venom, leading to symptoms that can range from mild local swelling to severe systemic reactions, including anaphylaxis. Understanding and recognizing the signs of a bee venom allergy is key to managing and treating this condition effectively....

Bee venom

Cocoa intolerance is a condition where individuals experience difficulty digesting cocoa, leading to gastrointestinal discomfort. This differs from a cocoa allergy, which involves an immune system response and can cause more severe reactions. Cocoa intolerance typically results in digestive symptoms after consuming cocoa or cocoa-based products....



Cocoa

Common pigweed is a prevalent weed known for causing allergic reactions in late summer and fall. Its pollen can be highly allergenic and is a common cause of hay fever and other allergic symptoms. Those sensitive to pigweed pollen may experience reactions during its peak pollination period....

Common Pigweed

Common ragweed is notorious for triggering fall allergies. As one of the most potent pollen producers, ragweed can affect individuals miles away from the actual plant. Its high pollen count is a prime cause of seasonal allergic rhinitis, which affects many people as the summer transitions to autumn....



Common Ragweed

Cottonwood trees, known for their cotton-like seeds, also produce pollen that can cause allergic reactions. During the spring, cottonwood trees release pollen that can aggravate allergies in sensitive individuals. This can lead to an increase in symptoms such as sneezing, congestion, and itchy eyes, particularly on windy days when the pollen is easily spread....



Cottonwood

Crayfish allergy is an allergic reaction to proteins found in crayfish, a type of shellfish. Similar to other shellfish allergies, it can range from mild to severe and can be potentially life-threatening in some cases. People with crayfish allergy may react not only to eating crayfish but also to inhaling steam from cooking crayfish....

Crayfish

Cucumber intolerance is a condition characterized by the body's difficulty in digesting cucumber, leading to gastrointestinal discomfort. This intolerance is distinct from a cucumber allergy, which involves an immune system response and can trigger more severe reactions. Cucumber intolerance typically results in digestive symptoms after consuming cucumbers....

Cucumber

Cultivated rye releases pollen that is a well-known cause of seasonal allergies. Its pollen season can overlap with grass pollen season, exacerbating symptoms for individuals with grass pollen allergies. When rye fields are flowering, nearby populations may experience a spike in hay fever symptoms....

Cultivated Rye

Pollen from cypress trees, prevalent in the spring and fall. Known to cause hay fever and asthma symptoms.

Cypress pollen

Dandelions, though often seen as a simple weed or a herbal remedy, can cause allergic reactions or intolerances in some individuals. This typically occurs due to the pollen they release or from direct contact with the plant. Understanding the potential for an allergic reaction to dandelions is important, especially during their peak blooming season....

Dandelion

Dermatophagoides farinae, or the American house dust mite, is a major allergen in household dust. These mites are ubiquitous in upholstered furniture, carpets, and bedding, where they feed on skin cells shed by humans. Their fecal matter and body fragments can cause allergic reactions year-round, often leading to allergic rhinitis and asthma....



Dermatophagoides farinae (D. farinae)

Food Intolerances

Goat's milk cheese intolerance is a condition where individuals experience difficulty digesting cheese made from goat's milk, a type of dairy product known for its unique flavor and texture. This can lead to gastrointestinal discomfort. Goat's milk cheese intolerance differs from a goat's milk cheese allergy, which involves an immune system response and can cause more severe reactions. People with goat's milk cheese intolerance typically experience digestive symptoms after consuming cheese made from goat's milk....

Goat’s milk cheese

Eel meat intolerance is a condition where individuals experience difficulty digesting eel meat, which is a type of seafood commonly consumed in various cuisines, particularly in Asia and Europe. This can lead to gastrointestinal discomfort. Eel meat intolerance differs from an eel meat allergy, which involves an immune system response and can cause more severe reactions. People with eel meat intolerance typically experience digestive symptoms after consuming eel meat or dishes containing it....

Goldenrod is often mistakenly blamed for hay fever; however, it's the less visible ragweed that blooms simultaneously and is a more potent allergen. Goldenrod pollen is heavy and sticky, not typically airborne. Allergic reactions to goldenrod are rare but possible, typically causing typical hay fever symptoms....



Goldenrod

Guinea pig allergies are caused by proteins found in the animal's dander, saliva, and urine. People with this allergy might experience symptoms when they come into contact with guinea pigs or their living environments. Symptoms can be immediate or develop over time with repeated exposure....



Guinea Pig

Shellfish that is a common allergen, causing symptoms such as hives, swelling, and anaphylaxis.

King crab

Hamster allergies are triggered by allergens found in the animal's dander, saliva, and urine. People with hamster allergies can have reactions from direct contact with the animal or from the allergens dispersed in the air. Such reactions are common in homes with these pets or in pet care facilities....

Hamster

Hazel trees are early bloomers, often heralding the start of the allergy season for many individuals. Their catkins release copious amounts of pollen as early as winter or spring, which can cause significant allergic reactions in people with sensitivities to tree pollen....

Hazel

Fertility Markers

Tangerines, sweet and tangy citrus fruits, are enjoyed for their refreshing taste and high vitamin C content. However, some individuals may experience tangerine intolerance, impacting their ability to consume tangerines without discomfort....



Tangerine

Pollen from hazelnut trees, known to cause respiratory allergies during its pollination period.

Hazelnut pollen

House dust allergies are triggered by various components of dust, including dust mites, pet dander, mold spores, and pollen. Symptoms can impair daily life, making it essential to minimize exposure and manage the home environment effectively....

House Dust

Pollen from olive trees, typically causing hay fever and other respiratory allergies during blooming periods.

Olive pollen

Citrus fruit that can provoke allergic reactions such as hives, digestive symptoms, and respiratory issues.

Orange

Ox-eye daisy is a charming perennial that can, unfortunately, trigger allergic reactions in sensitive individuals. Its pollen is less commonly allergenic compared to other plants but can still contribute to hay fever symptoms for those with a predisposition....

Ox-eye Daisy

Stone fruit that can cause allergies ranging from oral allergy syndrome to severe reactions like anaphylaxis.

Peach

Penicillium notatum is a common mold known for its role in producing penicillin. In the home, it may cause allergies, particularly in damp areas. Exposure to this mold can trigger respiratory symptoms and allergic reactions in sensitive individuals, especially those with mold allergies....

Penicillium notatum

Pork intolerance is a digestive condition where individuals have difficulty processing pork, leading to gastrointestinal discomfort. This intolerance is different from a pork allergy, which involves an immune system response and can cause more severe reactions. People with pork intolerance typically experience digestive symptoms after consuming pork....

Pork

Navigating the complexities of rabbit allergies involves understanding two distinct aspects: dietary intolerance to rabbit meat and allergic reactions to keeping rabbits as pets. Whether it's the consumption of rabbit meat that triggers symptoms or exposure to pet rabbits, being informed and cautious is crucial for those affected....

Rabbit

Plantain weed, not to be confused with the banana-like fruit, is a common allergen found in grassy areas. Its inconspicuous flowers release pollen that contributes to seasonal allergy symptoms. While not as prominent a pollen producer as other weeds, plantain can be problematic for those with specific sensitivities....

Plantain

Grain commonly used in foods around the world. Rice allergy can result in digestive and respiratory symptoms.

Rice

Russian thistle, also known as tumbleweed, can cause seasonal allergic reactions. Its pollen is a common allergen, especially in arid regions. During blooming seasons, the lightweight pollen can travel long distances, affecting many individuals. Symptoms are typical of hay fever and include sneezing, itchy eyes, and a runny nose....

Russian thistle

Pollen from rye grass, a significant cause of hay fever and respiratory allergies during its pollen season.

Rye pollen

Walnut intolerance is a condition where individuals have difficulty digesting walnuts, leading to gastrointestinal discomfort. This differs from a walnut allergy, which involves an immune system response and can cause more severe, sometimes immediate reactions. Walnut intolerance typically results in digestive symptoms after consuming walnuts....

Walnut

Shrimp allergy is a common type of shellfish allergy, involving an immune reaction to proteins found in shrimp. It's one of the most common food allergies in adults and can cause a range of symptoms from mild to severe, including the risk of anaphylaxis. Shrimp allergy is typically lifelong and can be triggered by eating shrimp or even by inhaling steam from cooking shrimp....



Shrimp

Walnut allergy is a type of tree nut allergy that is common and can cause serious reactions. The allergic reactions occur when the body's immune system mistakenly identifies proteins in walnuts as harmful. Symptoms can range from mild to severe and may include anaphylaxis. Individuals with walnut allergy may also experience cross-reactivity with other tree nuts and foods, making it crucial to identify and manage this allergy carefully....

Silkworm pupa, used in various cuisines and as a source of silk, can cause allergic reactions in some individuals. This allergy stems from proteins present in the silkworm pupae that trigger an immune response. Recognizing symptoms, avoiding triggers, and knowing how to manage an allergy to silkworm pupa are key steps for affected individuals....

Silkworm pupa

Wasp venom allergy is a serious condition that arises when an individual reacts allergically to the sting of a wasp. This allergy can cause symptoms ranging from localized pain and swelling to severe anaphylactic shock. Unlike bee stings, wasp stings can be particularly aggressive because wasps can sting multiple times, increasing the risk of a severe allergic reaction....

Wasp venom

Wheat allergy is an allergic reaction to proteins found in wheat. It's one of the most common food allergies, particularly in children, and should not be confused with celiac disease or gluten sensitivity, which are different conditions. Wheat allergy can cause a range of symptoms, from mild to severe, including the risk of anaphylaxis....




Wheat

Tyrophagus putrescentiae, also known as the mold mite, is found in various stored foods and household dust. These mites thrive in high humidity and can cause allergic reactions when their waste or body parts become airborne and inhaled by individuals with sensitivities, leading to various allergic symptoms....

Tyrophagus Putrescentiae

White ash trees contribute to seasonal pollen counts, particularly in the spring when they flower. The airborne pollen from white ash can trigger allergic reactions in sensitive individuals, adding to the array of tree pollens present during allergy season....

White Ash

Pollen from wormwood plants, known to cause hay fever and exacerbate asthma during its blooming season.

Wormwood ambrosia pollen

Willow trees release pollen early in the spring, contributing to seasonal allergy symptoms for many individuals. The light, easily dispersed pollen can provoke an immune response in those with a sensitivity to willow, leading to discomfort during what is often a beautiful time of year....

Willow

White pine trees, with their long, slender needles, are lesser-known contributors to pollen-related allergies. While their pollen is not as potent as that of some other trees, it can still cause symptoms in those with specific sensitivities, especially when pollen levels peak in the spring....

White Pine

Rosemary, a fragrant and aromatic herb used to flavor a wide range of dishes, is known for its distinctive scent and flavor profile. However, some individuals may experience rosemary intolerance, impacting their ability to consume rosemary without discomfort....

Salmon caviar

Minerals

Iodine is a vital mineral essential for thyroid health, playing a crucial role in producing thyroid hormones. These hormones regulate metabolism, growth, and energy production. While iodine occurs naturally in seafood, dairy, and some grains, deficiency is common, especially in areas with iodine-poor soil. Insufficient iodine can lead to thyroid disorders, impacting overall health. It's important to ensure adequate iodine intake for proper bodily functions....

Iodine

Anti-Müllerian Hormone (AMH) is a hormone produced by the ovaries that reflects a woman's ovarian reserve, indicating the number of eggs remaining in her ovaries. It helps assess fertility potential and is often measured in reproductive medicine....



Anti-Müllerian Hormone (AMH)

hCG, or human chorionic gonadotropin, is a hormone produced by the placenta during pregnancy. Its primary role is to support the development of the corpus luteum, which, in turn, produces progesterone to maintain the uterine lining for the embryo. hCG also plays a crucial role in preventing the degeneration of the corpus luteum, ensuring the continued production of progesterone....

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STIs

Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium Chlamydia trachomatis. It can infect both men and women and can cause serious, permanent damage to a woman's reproductive system, potentially leading to infertility. Chlamydia can also cause a potentially fatal ectopic pregnancy (pregnancy that occurs outside the womb)....



Chlamydia

Toxic elements

Antimony, used in flame retardants, electronics, and alloys, can be toxic if inhaled or ingested. Main risks include respiratory irritation, skin problems, and, in severe cases, heart and lung issues. Those working in industries that use antimony or living near manufacturing sites have higher exposure risks. Using appropriate safety equipment and monitoring air and water quality can help prevent antimony toxicity....



Antimony

Gardnerella, specifically referring to Gardnerella vaginalis, is a type of bacteria that is often associated with bacterial vaginosis (BV), a common vaginal infection. While Gardnerella is a normal part of the vaginal flora, an imbalance can lead to an overgrowth, resulting in BV. It is not considered a classic sexually transmitted infection (STI), but its occurrence can be influenced by sexual activity....



Gardnerella

Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae. It commonly affects the urethra, rectum, and throat, and in women, it can also infect the cervix. Gonorrhea is a common infection, especially among young people aged 15-24 years. It can lead to serious health problems and complications if not treated....



Gonorrhea

Barium is a soft, silvery metal used in various industries, including manufacturing and medical diagnostics. While barium sulfate in medical imaging is safe, exposure to soluble barium compounds can be harmful, affecting the heart, causing muscle weakness, and damaging the kidneys and liver. Industrial workers and individuals near barium processing plants are at increased risk of exposure through inhalation or water contamination....



Barium

HIV attacks the immune system, weakening the body's defense against infections. It's transmitted through bodily fluids, notably during unprotected sex or needle sharing. Early HIV might not show symptoms, making testing crucial. While there's no cure, antiretroviral therapy can manage the virus effectively. Prevention includes regular testing and prophylaxis medications like PrEP and PEP. Public health efforts emphasize education and stigma reduction....



Mycoplasma, particularly Mycoplasma hominis (MH), is a type of bacteria that can be transmitted through sexual contact, although it is not strictly classified as a sexually transmitted infection (STI). It is one of several species of Mycoplasma that affect humans and can inhabit the genital and respiratory tracts. While often asymptomatic, it can cause health problems, particularly in the genitourinary tract....



Mycoplasma (MH)

Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. It progresses through several stages if left untreated, including primary, secondary, latent, and tertiary syphilis, and can affect various organ systems over time. Syphilis is primarily spread through sexual contact, including oral, anal, and vaginal sex. It can also be transmitted from mother to child during pregnancy, leading to congenital syphilis....



Syphilis (Treponema Pallidum)

Beryllium, a lightweight metal used in aerospace, electronics, and nuclear industries, poses health risks when inhaled as dust or fumes. Beryllium exposure can lead to chronic beryllium disease (CBD), a serious lung condition, and skin diseases like dermatitis. The greatest risk occurs in industrial environments where beryllium is processed or machined....



Beryllium

Bismuth is a heavy metal commonly used in cosmetics, pharmaceuticals, and some alloys. While generally considered safe, excessive intake of bismuth, especially from medications like Pepto-Bismol, can lead to toxicity. Symptoms of bismuth toxicity include neurological problems, such as confusion and poor coordination. Most exposure to bismuth is through ingestion of bismuth-containing products....



Bismuth

Trichomonas, specifically referring to Trichomoniasis, is a sexually transmitted infection (STI) caused by a parasite called Trichomonas vaginalis. It is one of the most common curable STIs and can affect both men and women, although symptoms are more common in women. Trichomoniasis can cause irritation and increase the risk of acquiring other STIs, including HIV. ...



Trichomonas

Gadolinium is a rare earth metal used as a contrast agent in MRI scans. Though generally safe, there's concern about gadolinium deposits remaining in the body long after scans, particularly in individuals with kidney issues. Symptoms of gadolinium toxicity include skin thickening, bone pain, and cognitive disturbances....



Gadolinium

Ureaplasma is a group of tiny bacteria commonly found in the urogenital tracts of both men and women. They are part of the normal genital flora but can cause infection under certain conditions. Ureaplasma species, particularly Ureaplasma urealyticum and Ureaplasma parvum, are associated with a range of conditions such as urethritis, pelvic inflammatory disease (PID), and infertility. They can also be sexually transmitted, though they are not always classified strictly as STIs....



Ureaplasma

Vaginal pH refers to the level of acidity within the vaginal environment. The normal pH of the vagina is typically between 3.8 and 4.5, which is slightly acidic. This acidity is crucial for maintaining a healthy balance of bacteria and for preventing the growth of harmful organisms. Lactobacilli are the predominant bacteria in the vagina, and they produce lactic acid, which helps to keep the pH at a healthy level. Disturbances in vaginal pH can lead to infections and other gynecological health issues....



Vaginal pH

Gold, prized for its aesthetic and industrial value, can also pose health risks when exposure exceeds safe levels. Found in electronics, dentistry, and jewelry, gold rarely causes issues in small amounts. However, prolonged skin contact with gold-containing products or exposure to gold dust in industrial environments can lead to dermatitis and other allergic reactions. Inhalation of gold nanoparticles is a concern in manufacturing settings, potentially affecting respiratory health....



Gold

Palladium, a metal used in electronics, jewelry, and dental materials, can be toxic if inhaled or ingested in large amounts. Occupational exposure is the most common risk, leading to respiratory, skin, and digestive issues. Palladium allergy is also possible, causing dermatitis....



Palladium

Silver has various uses in industry and medicine but can turn toxic with significant human exposure. Small silver amounts are normal in the environment and products. Yet, too much exposure risks health issues like argyria. This condition permanently turns the skin blue-gray. Eating, breathing in, or touching silver compounds can cause argyria and might harm the liver and kidneys....



Silver

Tin, found in various alloys, food packaging, and electronics, is generally low in toxicity. However, certain organic tin compounds used in industrial processes can pose health risks, such as skin and eye irritation, digestive issues, and in extreme cases, neurological problems. Those handling tin in manufacturing or using tin-containing products should be aware of potential risks. Avoiding unnecessary exposure to organic tin compounds and adhering to safety guidelines are key to preventing tin toxicity....



Titanium is widely used in medical implants, cosmetics, and paints, known for its strength and corrosion resistance. While elemental titanium is considered safe, inhalation of titanium dioxide particles, especially in powder form, can cause respiratory issues. Workers in industries processing titanium materials and users of certain cosmetics might face exposure risks. Adopting safety protocols and using protective equipment can help prevent inhalation of titanium particles....



Titanium

Uranium, a radioactive element used in nuclear power and weapons, poses health risks primarily through radiation exposure and chemical toxicity. Ingesting or inhaling uranium can damage the kidneys and increase cancer risk due to its radioactivity. The most significant exposure risks come from living near uranium mining, processing facilities, or contaminated sites. Reducing exposure involves using water filters and following safety guidelines in affected areas....



Uranium

Platinum, a precious metal used in automotive catalytic converters, jewelry, and chemotherapy drugs, poses health risks when inhaled or comes into prolonged skin contact. Workers in industries that use platinum and people wearing platinum-based jewelry may experience allergic reactions, respiratory issues, and skin irritation. Avoiding excessive exposure and using protective gear in industrial settings can mitigate health risks....



Platinum

AHCY: Encodes the enzyme adenosylhomocysteinase, which plays a central role in the conversion of S-adenosylhomocysteine to homocysteine, a critical step in the body's methylation processes and detoxification....



AHCY

MTRR (Methionine Synthase Reductase): MTRR is crucial for regenerating methylcobalamin, ensuring the continuous function of MTR in homocysteine metabolism. It plays a key role in maintaining adequate methionine levels and supports normal DNA synthesis. MTRR mutations are associated with homocystinuria, which can lead to developmental and neurological issues. Insights into MTRR function offer potential for genetic disorder therapies....



MTRR

SMARCA2 (SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 2): SMARCA2 is a core component of the SWI/SNF chromatin remodeling complex, playing a pivotal role in regulating gene expression by altering chromatin structure. Mutations in SMARCA2 are associated with disorders like Nicolaides-Baraitser syndrome, characterized by intellectual disability and sparse hair. Its function is critical for proper gene regulation and development....



SMARCA2

FANCA (Fanconi anemia group A protein): FANCA is a critical component of the Fanconi anemia (FA) pathway, a DNA repair mechanism essential for maintaining genomic stability and preventing chromosomal instability. This protein is involved in the activation of the FA core complex, which functions in the recognition and repair of DNA interstrand crosslinks (ICLs). ICLs are highly toxic DNA lesions that can block DNA replication and transcription, leading to genome instability and cell death if left unrepaired. FANCA plays a pivotal role in coordinating the assembly of the FA core complex and its recruitment to sites of DNA damage, where...



FANCA

PLTP (Phospholipid Transfer Protein): PLTP, also known as phospholipid transfer protein, is a key player in lipid metabolism and lipid transport processes within the body. It facilitates the transfer of phospholipids, such as phosphatidylcholine and phosphatidylethanolamine, between different lipoprotein particles, thereby regulating their composition and metabolism. PLTP plays a crucial role in the maintenance of plasma lipoprotein homeostasis, influencing the size, composition, and functionality of various lipoprotein fractions, including high-density lipoproteins (HDL) and low-density lipoproteins (LDL). Its activity is essential for processes like reverse cholesterol transport, which removes excess cholesterol from peripheral tissues and delivers it to the liver for...



PLTP

SOAT2 (Sterol O-Acyltransferase 2): SOAT2, a member of the sterol O-acyltransferase family, is a crucial enzyme involved in lipid metabolism, particularly in the esterification of cholesterol. This enzyme plays a significant role in the regulation of cellular cholesterol levels by converting free cholesterol into cholesterol esters, which are stored in lipid droplets or incorporated into lipoproteins for transportation. SOAT2 is primarily expressed in tissues involved in lipid metabolism, such as the liver, intestine, and macrophages. Its activity is tightly regulated and responsive to cellular cholesterol levels, serving as a key mechanism to prevent cholesterol toxicity and maintain lipid homeostasis. Dysregulation...



SOAT2

SLC1A7 (Solute Carrier Family 1 Member 7): SLC1A7 is a high-affinity glutamate transporter, primarily involved in the clearance of glutamate from the synaptic cleft. Its role is crucial in preventing excitotoxicity, a condition where excessive glutamate causes neuronal damage. While less studied than other glutamate transporters, SLC1A7 contributes to the regulation of glutamatergic signaling, with potential implications for neurological conditions characterized by dysregulated glutamate neurotransmission....



SLC1A7

SLC22A5 (Solute Carrier Family 22 Member 5): SLC22A5, also known as OCTN2, is a crucial carnitine transporter, responsible for the cellular uptake of carnitine, a necessary compound for the transport of fatty acids into mitochondria for oxidation. This process is vital for energy production in various tissues, especially the heart and muscles. Mutations in the SLC22A5 gene can lead to primary carnitine deficiency, a condition characterized by muscle weakness and cardiomyopathy, underscoring its essential role in metabolic health and energy homeostasis....



SLC22A5

VEGFC, or Vascular Endothelial Growth Factor C, is a crucial protein involved in the regulation of lymphangiogenesis, the formation of lymphatic vessels, and angiogenesis, the formation of blood vessels. As a member of the vascular endothelial growth factor (VEGF) family, VEGFC plays diverse roles in physiological and pathological processes, including embryonic development, tissue repair, and tumor progression. One of the primary functions of VEGFC is its ability to stimulate the growth and proliferation of lymphatic endothelial cells, promoting the formation and remodeling of lymphatic vessels. VEGFC binds to and activates its receptors, primarily VEGFR-3 (vascular endothelial growth factor receptor 3), initiating...



VEGFC

EDA2R, also known as Ectodysplasin A2 receptor, is a protein encoded by the EDA2R gene. It belongs to the tumor necrosis factor receptor (TNFR) superfamily and serves as a receptor for ectodysplasin A2 (EDA-A2), a signaling molecule involved in the development of ectodermal tissues such as hair, teeth, and sweat glands. One of the primary functions of EDA2R is its role in mediating the effects of EDA-A2 signaling during embryonic development. EDA-A2, also known as ectodysplasin A2 or EDA2, is a ligand that binds to EDA2R, initiating signaling cascades that regulate the formation and patterning of ectodermal structures. This signaling pathway...



EDA2R

Japanese cedar, also known as Cryptomeria, is notorious for producing highly allergenic pollen. This pollen can trigger a condition known as "cedar fever," characterized by severe allergic reactions. Pollen release typically occurs from winter to early spring and can be intense, affecting a large number of individuals where these trees are prevalent....

Japanese Cedar

Almond allergy is an allergic reaction to almonds, a type of tree nut. It is one of the more common tree nut allergies and can range from mild to severe, including potentially life-threatening reactions. Like other food allergies, an almond allergy is an immune system response to the proteins found in almonds....

Almond

Japanese hop, an invasive climbing plant, blooms in late summer and releases pollen that can cause allergic reactions. People who are sensitive to this type of pollen may experience increased symptoms during this time, especially in urban areas where the plant is more common....

Japanese Hop

Fruit that is widely consumed fresh, in pies, and as juice. Known to cause oral allergy syndrome in some individuals.

Apple

Pollen from ash trees, which is a common allergen during springtime. Can induce respiratory symptoms in allergic individuals.

Ash (pollen)

Allergies to fruits such as kiwi, mango, and banana are increasingly recognized and can cause discomfort and severe reactions in sensitive individuals. These allergies stem from the body's immune system reacting to specific proteins found in these fruits, leading to a range of symptoms. Recognizing these allergies and managing them effectively is vital for maintaining health and well-being....

Kiwi, Mango, Banana

Grass pollen that is a significant cause of seasonal allergies, especially in late spring and early summer.

Bahia grass (pollen)

Red meat that can cause allergic reactions, including hives, gastrointestinal symptoms, and anaphylaxis in some individuals.

Beef

Bermuda grass pollen allergy is a type of allergic reaction to the pollen grains released by Bermuda grass, a common grass species in warmer regions, especially used for lawns, parks, and golf courses. This allergy is a form of seasonal allergic rhinitis, often flaring up during the grass-pollinating seasons, typically late spring and summer....

Bermuda grass (pollen)

Blood

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Ribwort plantain pollen

Description

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